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JAMA Diagnostic Test Interpretation
September 26, 2017

Aspergillus Galactomannan for Diagnosing Invasive Aspergillosis

Author Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
  • 2Division of Infectious Diseases, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan
JAMA. 2017;318(12):1175-1176. doi:10.1001/jama.2017.10661

A 67-year-old man with granulomatous polyangiitis (Wegener granulomatosis) complicated by end-stage renal disease requiring hemodialysis and mild pulmonary fibrosis, was hospitalized with a 2-week history of worsening dyspnea and dry cough. He was taking 20 mg prednisone and 150 mg azathioprine daily.

On examination, he was afebrile and had diffuse rhonchi and expiratory wheezes. A chest computed tomography (CT) scan revealed bilateral nodular infiltrates and a 1.3-cm cavitary nodule in the right upper lobe. Bronchoscopy was performed on day 2. Blood and bronchoalveolar lavage fluid test results are presented in the Table.