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From The Medical Letter on Drugs and Therapeutics
September 26, 2017

Safety of Long-Term PPI Use

JAMA. 2017;318(12):1177-1178. doi:10.1001/jama.2017.13272

Proton pump inhibitors (PPIs), which are used for treatment of gastroesophageal reflux disease (GERD) and for prevention of upper gastrointestinal adverse effects caused by NSAIDs and aspirin, are one of the most commonly prescribed classes of drugs in the US (Table). All PPIs are similarly effective and generally well tolerated,1,2 but their long-term use has been associated with a number of safety concerns.3,4 Recommendations addressing these concerns have recently been published.5,6

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