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September 26, 2017

Extracorporeal Organ Support: From Technological Tool to Clinical Strategy Supporting Severe Organ Failure

Author Affiliations
  • 1Department of Anesthesia and Intensive Care Medicine, Sapienza Università di Roma, Policlinico Umberto I, Rome, Italy
  • 2Division of Pulmonary, Allergy, and Critical Care Medicine, College of Physicians and Surgeons, Columbia University, New York, New York
  • 3New York–Presbyterian Hospital, New York, New York
  • 4Department of Intensive Care, Université Libre de Bruxelles, Brussels, Belgium
JAMA. 2017;318(12):1105-1106. doi:10.1001/jama.2017.10108

Mechanical ventilation, renal replacement therapy, and artificial liver detoxification circuits are among the systems designed to support or replace organs compromised by trauma, sepsis, or acute respiratory, kidney, or liver failure. Among these systems, extracorporeal membrane oxygenation (ECMO) has recently generated increasing expectations despite results from early clinical trials in adults that suggested ECMO use should be restricted to only those patients determined by specialized clinicians to have a very high risk of mortality.

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