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December 18, 1943

O lechebnom deystvii antiretikulyarnoy tsitotoksicheskoy syvorotki "ATsS

JAMA. 1943;123(16):1083. doi:10.1001/jama.1943.02840510077034

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This small volume contains reports on the therapeutic effect of the antireticular cytotoxic serum. The new therapeutic agent, the result of years of research by Prof. A. A. Bogomolets, is based on the conception that the connective tissue of an organism contains a number of hitherto uninvestigated physiologic functions. The aim of the antireticular cytotoxic serum is to stimulate these functions and to intensify active immunity.

The serum is produced by the immunization of horses with the cells of the spleen and bone marrow taken from a human corpse. The determination of the amount of cytotoxins in the serum obtained is important. It was found that the amount of cytotoxins in the serum of the immunized animal can be determined by applying a modification of the reaction of complement fixation (the reaction of Bordet-Gengou), that is, by using an antigen for the reaction of complement fixation, the same antigen as

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