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Comment & Response
October 3, 2017

Effect of Different Iron Preparations for Young Children With Iron-Deficiency Anemia—Reply

Author Affiliations
  • 1Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas
  • 2Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas
  • 3Division of Hematology/Oncology, Cook Children’s Medical Center, Fort Worth, Texas
JAMA. 2017;318(13):1282-1283. doi:10.1001/jama.2017.11941

In Reply Dr Fujita correctly notes that infants and young children treated with ferrous sulfate in the trial had the most rapid change in hemoglobin concentration within the first 4 weeks of therapy initiation. Based on the similar rate of change in hemoglobin concentration thereafter (4-12 weeks), the suggestion was made that iron polysaccharide complex may be as efficacious as ferrous sulfate in patients with mild cases of IDA. However, an analysis of patients with mild IDA in the study does not support this conclusion.

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