In Reply Dr Fujita correctly notes that infants and young children treated with ferrous sulfate in the trial had the most rapid change in hemoglobin concentration within the first 4 weeks of therapy initiation. Based on the similar rate of change in hemoglobin concentration thereafter (4-12 weeks), the suggestion was made that iron polysaccharide complex may be as efficacious as ferrous sulfate in patients with mild cases of IDA. However, an analysis of patients with mild IDA in the study does not support this conclusion.
Powers JM, Buchanan GR, McCavit TL. Effect of Different Iron Preparations for Young Children With Iron-Deficiency Anemia—Reply. JAMA. 2017;318(13):1282–1283. doi:10.1001/jama.2017.11941
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