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October 10, 2017

Using Antimüllerian Hormone to Predict Fertility

Author Affiliations
  • 1University of Colorado School of Medicine, Aurora
JAMA. 2017;318(14):1333-1334. doi:10.1001/jama.2017.14954

Antimüllerian hormone (AMH) is a transforming growth factor β superfamily peptide that is a product of the ovarian follicle.1 This hormone is present in small, growing follicles but not in primordial follicles, and its production decreases as follicles go through the terminal stages of maturation. Because the “available” pool of early growing follicles is believed to be a more or less fixed proportion of the total follicle pool (primordial plus growing follicles), AMH provides a direct assessment of ovarian reserve. Antimüllerian hormone levels have been shown to decline across the reproductive life span in cross-sectional studies2-4 and to decline over time in the same woman undergoing repeated measurements.5 Highly sensitive measurement methods for AMH are helpful in predicting the timing of a woman’s final menstrual period.6