To the Editor Dr Donohue and colleagues1 found that elevated brain amyloid levels in cognitively normal individuals, compared with normal brain amyloid levels, were associated with a higher likelihood of cognitive decline. However, we have some concerns about the strength of their conclusions based on the cerebrospinal fluid (CSF) biomarkers analyzed, different ratios for the methods of amyloid measurement in each group, and unclear details of surgical operations.
Gao R, Chen C, Zhu T. Elevated Brain Amyloid in Cognitively Normal Individuals. JAMA. 2017;318(14):1392–1393. doi:10.1001/jama.2017.12951
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