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Research Letter
October 17, 2017

Acute Zika Virus Infection as a Risk Factor for Guillain-Barré Syndrome in Puerto Rico

Author Affiliations
  • 1Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, San Juan, Puerto Rico
  • 2National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
  • 3Office for State, Tribal, Local, and Territorial Support, Centers for Disease Control and Prevention, San Juan, Puerto Rico
  • 4University of Puerto Rico, San Juan, Puerto Rico
  • 5Office of Epidemiology and Research, Puerto Rico Department of Health, San Juan, Puerto Rico
JAMA. 2017;318(15):1498-1500. doi:10.1001/jama.2017.11483

Guillain-Barré syndrome (GBS) is an uncommon autoimmune disorder characterized by progressive weakness and diminished deep tendon reflexes following infection or, rarely, vaccination.1 Increased GBS incidence has been reported in countries affected by Zika virus,2 a flavivirus transmitted primarily by Aedes species mosquitoes.3 During the Zika virus epidemic in Puerto Rico, we conducted a case-control study to identify risk factors associated with GBS.

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