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The author presents from his own experiences and those of his associates the clinical syndrome and blood chemistry encountered with a depletion of body chloride. Chloropénie autonome is used to designate that condition in which there is a loss of chloride ion both from the blood and from other body tissues. It is usually accompanied by a high alkali reserve. This condition is distinguished from a hypochloremia due to a migration of the chlorine ion from blood to tissue and usually associated with a low alkali reserve. Either case is apt to be accompanied with nitrogen retention. According to the author, the increase in blood nitrogen observed in chloropénie autonome is due to a renal lesion produced as the result of the low salt concentration. He discredits the theory that there is a retention of nitrogen unassociated with a kidney insufficiency in order to maintain the osmotic pressure of the
L'hypochlorémie.. JAMA. 1931;97(11):802. doi:10.1001/jama.1931.02730110052035
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