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April 20, 1929


JAMA. 1929;92(16):1372. doi:10.1001/jama.1929.02700420056023

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To the Editor:  —In The Journal, March 30, page 1141, "M.D., Ohio" inquires about the use of glandular therapy to stimulate ovarian (i. e., oogenetic) function in order that pregnancy may occur. Your reply says, in substance, that endocrine therapy in such cases has proved unsatisfactory. This statement is so much at variance with the views, based on a considerable experience, of our clinical group, that I should like the opportunity of placing on record a different opinion.We agree that the endocrine therapy of sterility, as commonly practiced, is worthless. It is far from worthless, however, if three conditions are properly fulfilled. These conditions are as follows:

  1. There must be a definite insufficiency on the part of one of the endocrine glands, so that the exhibition of a single glandular product fills a specific need and is true replacement therapy.

  2. The necessary product must be given in adequate dosage

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