In this issue of JAMA, Ehteshami Bejnordi et al1 evaluate and compare the ability of 32 computer algorithms to identify the presence and location of metastatic lesions on pathology slide images of sentinel axillary lymph nodes from women with breast cancer. The authors used free-response receiver operating characteristic (FROC) curve analysis to assess diagnostic and localization accuracy. They found that the best algorithm performed similarly to a pathologist working without a time constraint (Figure).
Moskowitz CS. Using Free-Response Receiver Operating Characteristic Curves to Assess the Accuracy of Machine Diagnosis of Cancer. JAMA. 2017;318(22):2250–2251. doi:10.1001/jama.2017.18686
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