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JAMA Guide to Statistics and Methods
December 12, 2017

Using Free-Response Receiver Operating Characteristic Curves to Assess the Accuracy of Machine Diagnosis of Cancer

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
JAMA. 2017;318(22):2250-2251. doi:10.1001/jama.2017.18686

In this issue of JAMA, Ehteshami Bejnordi et al1 evaluate and compare the ability of 32 computer algorithms to identify the presence and location of metastatic lesions on pathology slide images of sentinel axillary lymph nodes from women with breast cancer. The authors used free-response receiver operating characteristic (FROC) curve analysis to assess diagnostic and localization accuracy. They found that the best algorithm performed similarly to a pathologist working without a time constraint (Figure).