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Article
February 26, 1944

PURIFICATION OF THE POLIOMYELITIC VIRUSES

JAMA. 1944;124(9):578. doi:10.1001/jama.1944.02850090034013
Abstract

Recently the study of poliomyelitis was taken up by the Institute of Physical Chemistry at the University of Uppsala, Sweden. This study at present centers on the poliomyelitic virus, its properties and reactions, in the hope that a basis may be built for attempts at chemotherapy and chemoprophylaxis of the disease. The first steps in that direction, namely the purification of the viruses of mouse encephalomyelitis (Theiler's disease) and of human poliomyelitis, are described in detail by Gard.1 He has taken advantage of the close similarities of the two viruses, especially with respect to particle size and to the host reactions to infection, and is using the mouse virus as a model virus which can be studied in its natural host.

From a careful analysis of the present knowledge of these two viruses and of the virus of infectious swine paralysis (encephalomyelitis enzootica suum, also called the Teschen disease, from

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