Following the announcement of the experimental results of the Oxford workers,1 studies on penicillin were initiated at the Presbyterian Hospital in the autumn of 1940 and have been carried forward continuously up to the present time. The results of the biologic and chemical phases of the investigation have been reported from time to time elsewhere.2 In the early stages of the work little attention was paid to the clinical aspects of the problem because of difficulties encountered in producing quantities sufficient for therapeutic purposes and because of the desire to utilize such material as became available for chemical and experimental studies. Enough material was produced, however, to demonstrate that the product was essentially nontoxic for man, and a limited number of patients were treated both locally and systemically.
For preliminary clinical trial, cases of subacute bacterial endocarditis were selected because of the known refractoriness of this disease to
DAWSON MH, HOBBY GL. THE CLINICAL USE OF PENICILLINOBSERVATIONS IN ONE HUNDRED CASES. JAMA. 1944;124(10):611–622. doi:10.1001/jama.1944.02850100001001
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