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September 26, 1931


JAMA. 1931;97(13):940-941. doi:10.1001/jama.1931.02730130044020

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Viosterol in the Treatment of Osteomalacia  The power to fix calcium, which is ascribed incontestably to viosterol and has caused it to become the preferred remedy in rickets, appeared at an early date to be utilizable in a disease due evidently to hypocalcemia; namely, osteomalacia. It has been used in this manner in Germany, where osteomalacia is much more frequent than in France. Harvier and A. Lafitte presented recently before the Société des médecins des hôpitaux de Paris a case in which osteomalacia manifested itself by pains in the bones, a sinking of the thorax into the pelvis, multiple spontaneous fractures, and a rarefaction of the bones. Examination of the blood showed a general hypocalcemia, together with hypophosphatemia. Three years previously, the patient had been treated for an attack of tetany. At the age of 28, she had undergone an ovariotomy and for many years she had been subjected to

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