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Comment & Response
January 16, 2018

Risks of Statins for Lower-Risk Individuals—Reply

Author Affiliations
  • 1Yale School of Medicine, New Haven, Connecticut
JAMA. 2018;319(3):310. doi:10.1001/jama.2017.19174

In Reply I stand by my statement that “For lower-risk individuals, treatment with statins provides a smaller benefit, but many will find the benefits to outweigh risks.” The lower the absolute risk, the smaller the benefit from statins, but what one person considers a meaningful risk reduction might differ from the view of another. Dr Regenold states that numerous brain disorders are associated with statin use but cites an article that lacks any strong clinical evidence to support that claim. Although it is appropriate to be vigilant in identifying harms of any therapy, physicians must also be careful not to rely on weak evidence and speculation to suggest that there is harm when it has yet to be demonstrated.