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JAMA Clinical Evidence Synopsis
January 23/30, 2018

Oral Medications to Treat Toenail Fungal Infection

Author Affiliations
  • 1Primary Care Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Australia
  • 2Faculty of Medicine, University of Queensland and Princess Alexandra Hospital, Brisbane, Australia
JAMA. 2018;319(4):397-398. doi:10.1001/jama.2017.20160

Clinical Question  Which oral antifungal medication is associated with the highest clinical (ie, normal appearance of the toenail) and mycological (negative culture, microscopy, or both) cure rates vs placebo or other antifungals when used to treat fungal infections?

Bottom Line  Both terbinafine and azole-based medications were associated with higher clinical and mycological cure rates compared with placebo (high-quality evidence). Azoles were associated with lower cure rates than terbinafine when compared directly.