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JAMA Guide to Statistics and Methods
February 13, 2018

The Stepped-Wedge Clinical Trial: Evaluation by Rolling Deployment

Author Affiliations
  • 1Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia
JAMA. 2018;319(6):607-608. doi:10.1001/jama.2017.21993

Cluster randomized trials are studies in which groups of individuals, for example those associated with specific clinics, families, or geographical areas, are randomized between an experimental intervention and a control.1 A stepped-wedge design is a type of cluster design in which the clusters are randomized to the order in which they receive the experimental regimen. All clusters begin the study with the control intervention, and by the end of the trial (assuming no unexpected and unacceptable safety issues arise), all clusters are receiving the experimental regimen.