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Comment & Response
February 13, 2018

Early Resuscitation for Adults With Sepsis in a Low-Income Country

Author Affiliations
  • 1Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
JAMA. 2018;319(6):614. doi:10.1001/jama.2017.20406

To the Editor Dr Andrews and colleagues1 performed a randomized clinical trial of a sepsis protocol for early resuscitation involving intravenous fluids, vasopressors, and blood transfusion compared with usual care among adults with sepsis and hypotension in Zambia. They found that in-hospital mortality was greater in the sepsis protocol group than in the usual care group. However, the difference in mortality may not be attributed solely to the early resuscitation protocol.