Contact precautions (CPs), the use of gloves and gowns, have been widely used for many years to prevent pathogen transmission between patients in health care facilities. The US Centers for Disease Control and Prevention has recommended CPs for patients infected with multidrug-resistant organisms for decades, including in its most recent guidance.1 Despite this recommendation, adherence is often variable, owing largely to perceptions that CPs are burdensome to use. Observational studies also suggest that CPs are costly, reduce health care worker interactions with patients, and increase anxiety and depression among patients.