In this issue of JAMA, Jabre et al1 report the results of an ambitious randomized noninferiority trial comparing bag-mask ventilation (BMV) with endotracheal intubation (ETI) in the treatment of 2043 adult patients who experienced cardiac arrest in the out-of-hospital setting, with a primary dichotomous outcome of survival with favorable neurological outcome. During the trial, performed in France and Belgium, 4.3% of patients treated with BMV (n = 1020) compared with 4.2% of patients treated with ETI (n = 1023) achieved the primary outcome, defined as favorable neurological outcome at 28 days based on Cerebral Performance Category 1 or 2 (between-group difference, 0.11% [1-sided 97.5% CI, −1.64% to infinity]; P for noninferiority = .11).
Lewis RJ, Gausche-Hill M. Airway Management During Out-of-Hospital Cardiac Arrest. JAMA. 2018;319(8):771–772. doi:10.1001/jama.2018.0155
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