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JAMA Clinical Evidence Synopsis
February 27, 2018

Gabapentin for Chronic Neuropathic Pain

Author Affiliations
  • 1Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England
JAMA. 2018;319(8):818-819. doi:10.1001/jama.2017.21547

Clinical Question  Is gabapentin associated with pain relief in people with chronic neuropathic pain?

Bottom Line  Oral gabapentin (1200-3600 mg/d for 4-12 weeks) for patients with moderate or severe neuropathic pain from postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN) is associated with pain reduction of at least 50% in 14% to 17% more patients than placebo.