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In This Issue of JAMA
February 27, 2018


JAMA. 2018;319(8):745-747. doi:10.1001/jama.2017.12251

Studies of cardiopulmonary resuscitation have reported an increased risk of mortality in patients receiving endotracheal intubation. A trial by Jabre and colleagues that randomized 2043 patients with out-of-hospital cardiorespiratory arrest to receive bag-mask ventilation or endotracheal intubation was inconclusive. In an Editorial, Lewis and Gausche-Hill suggest that a more informative outcome for future studies of resuscitation would score the severity of neurological impairment.



Meropenem-vaborbactam has potent in vitro activity against antibiotic-resistant Enterobacteriaceae. In a randomized trial that enrolled 550 patients with complicated urinary tract infections, Kaye and colleagues found meropenem-vaborbactam to be noninferior to piperacillin-tazobactam for the composite outcome of complete resolution or improvement of symptoms with microbial eradication.


Professional football players are well-conditioned athletes at risk for repetitive trauma and substance abuse. In a retrospective cohort study of 3812 retired US National Football League (NFL) players, Venkataramani and colleagues found that career participation in the NFL, compared with limited NFL exposure as a replacement player during a league-wide strike, was not associated with a statistically significant difference in long-term all-cause mortality. In an Editorial, DeKosky and colleagues recommend that future studies of elite athletes should address their quality of life.

Editorial and JAMA Patient Page

Author Audio Interview

Varicose veins and other vascular diseases may be caused by inflammation. In a retrospective cohort study of claims data for 425 968 patients, Chang and colleagues found that patients with varicose veins had an increased risk of deep venous thrombosis.


Clinical Review & Education

In this Clinical Evidence Synopsis summarizing a Cochrane review of 37 randomized trials, Moore and colleagues discuss the use of gabapentin for neuropathic pain. An Editorial by Wallach and Ross outlines the history of gabapentin availability in the United States and recommends improvements in postmarket surveillance to ensure that approved drugs are safe and effective for new indications.


In this JAMA Clinical Guidelines Synopsis of a 2016 guideline developed by the American Heart Association and the American Stroke Association, Gittler and Davis discuss the care of patients who are recovering from stroke.

This Medical Letter on Drugs and Therapeutics compares the safety and efficacy of a new 2-dose vaccine with that of the previous 3-dose vaccine for the prevention of hepatitis B infection in adults.

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