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Clinical Trials Update
February 27, 2018

High-Intensity Exercise Safe in De Novo Parkinson Disease

JAMA. 2018;319(8):761. doi:10.1001/jama.2018.1200

Clinicians can safely prescribe high-intensity exercise to patients with Parkinson disease who are not yet taking medication, found a phase 2 trial published in JAMA Neurology.

The 128 participants with de novo Parkinson disease were randomized to engage in high-intensity exercise (4 times per week at 80%-85% of maximum heart rate), moderate-intensity exercise (4 times per week at 60%-65% of maximum heart rate), or to a control group on a wait list for 6 months.