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JAMA Clinical Evidence Synopsis
March 6, 2018

Procalcitonin Testing to Guide Antibiotic Therapy in Acute Upper and Lower Respiratory Tract Infections

Author Affiliations
  • 1Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
  • 2Faculty of Medicine, University of Basel, Basel, Switzerland
JAMA. 2018;319(9):925-926. doi:10.1001/jama.2018.0852

Clinical Question  Is the use of procalcitonin for guiding antibiotic decisions in patients with acute upper and lower respiratory tract infections associated with improved clinical outcomes compared with usual care?

Bottom Line  Among patients with varying types and severity of acute respiratory infection, using procalcitonin to guide decisions about antibiotics is associated with lower rates of antibiotic exposure, antibiotic-related adverse effects, and mortality.