The beneficial effect of lipid lowering with statins in randomized clinical trials has had a profound effect on patient outcomes and informing treatment algorithms for cardiovascular prevention. These studies have increasingly emphasized the importance of the direct relationship between the degree of lipid lowering and clinical benefit, with the greatest effect observed among patients at the highest risk of having a subsequent cardiovascular event.1 Such observations have informed treatment guidelines, which strongly advocate for use of intensive statin therapy for patients with the highest cardiovascular risk.2
Nicholls SJ, Psaltis PJ. Lipid Lowering in Acute Coronary Syndrome: Is Treatment Early Enough? JAMA. 2018;319(13):1325–1326. doi:10.1001/jama.2018.2426
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