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Comment & Response
March 27, 2018

Vaccination Strategies During Shortages of Yellow Fever Vaccine

Author Affiliations
  • 1Department of Dermatology, Children’s National Health System, Washington, DC
  • 2Office of the Director, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
JAMA. 2018;319(12):1280. doi:10.1001/jama.2018.0200

To the Editor Drs Chen and Hamer summarized public health challenges posed by global shortages of yellow fever (YF) virus vaccines and new vaccination strategies adopted to control deadly ongoing YF outbreaks.1 A single subcutaneous dose of live-attenuated YF vaccine will elicit lifelong protective immunity within 10 days in nearly all vaccinees. This is the rationale for the vaccination requirements from the World Health Organization (WHO) for cross-border travel. But, as Chen and Hamer noted, depletion of international YF vaccine stockpiles necessitated vaccine dose-sparing methods to control epidemics. The most widely adopted method is to administer a fraction of the standard vaccine dose in the usual subcutaneous manner.

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