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Clinical Trials Update
March 27, 2018

Similar IVF Birth Rates for Frozen and Fresh Embryos

JAMA. 2018;319(12):1190. doi:10.1001/jama.2018.2150

Two recent trials published in the New England Journal of Medicine found that otherwise healthy infertile women without polycystic ovaries had similar rates of ongoing pregnancy and live births from in vitro fertilization (IVF) regardless of whether the transferred embryos were fresh or frozen.

A previous large trial found that the transfer of frozen embryos led to a higher live-birth rate than fresh embryos in women with infertility caused by polycystic ovary syndrome (PCOS). Other smaller trials have also demonstrated higher pregnancy rates and perinatal outcomes with frozen-embryo transfer, which has become increasingly common. The aim of this pair of recent trials was to determine if frozen-embryo transfer increased the birth rate among women undergoing IVF whose infertility was not associated with PCOS.