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April 3, 2018

Platelets’ Role in Adaptive Immunity May Contribute to Sepsis and Shock

JAMA. 2018;319(13):1311-1312. doi:10.1001/jama.2017.12859

Previous research has shown platelets are involved in the innate immune response to pathogens via toll-like receptor expression, and evidence is emerging that they may also be important for adaptive immunity. A new study published in the Proceedings of the National Academy of Sciences has uncovered an unappreciated role of platelets in antibody-mediated adaptive immune responses.

“The fact that human platelets express a receptor for IgG antibody, while murine platelets are completely devoid of any receptor for IgG, explains why these observations had been overlooked,” said senior author Éric Boilard, PhD, a professor at Université Laval and Centre hospitalier universitaire de Québec Research Centre, in Canada.

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