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JAMA Diagnostic Test Interpretation
April 3, 2018

Evaluation of the Direct Antiglobulin Test (DAT) in the Setting of Mycoplasma pneumoniae Infection

Author Affiliations
  • 1Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 2McGaw Medical Center of Northwestern University, Chicago, Illinois
JAMA. 2018;319(13):1377-1378. doi:10.1001/jama.2018.1969

A young adult was diagnosed with community-acquired pneumonia after presenting with productive cough and fevers. Despite treatment, she remained febrile and was hospitalized due to progressive hypoxemia, a pleural effusion, and bilateral pulmonary emboli. Laboratory tests revealed new-onset anemia, thrombocytosis, and red blood cell (RBC) agglutination (Table). Direct antiglobulin test (DAT) results were positive. Subsequent testing revealed an elevated Mycoplasma pneumoniae titer.

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