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Comment & Response
April 17, 2018

Diagnosis and Treatment of Hidradenitis Suppurativa

Author Affiliations
  • 1Department of Radiation Oncology, Edward Hines Jr Veterans Affairs Hospital, Maywood, Illinois
JAMA. 2018;319(15):1618. doi:10.1001/jama.2018.0818

To the Editor The article on HS1 reviewed old and new medical and surgical treatments but omitted any mention of radiation therapy.

HS, along with acne conglobata and dissecting cellulitis, constitute the “follicular occlusion triad.” All 3 conditions are frequently complicated by secondary infections, which may exacerbate and perpetuate the conditions, and malignant degeneration has been reported.2 Such malignant degeneration is akin to development of Marjolin's ulcers, which are squamous cell carcinomas developing in areas of scarring and chronic inflammation following burns, cutaneous ulceration, and discoid lupus erythematosus.

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