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JAMA Clinical Evidence Synopsis
April 24, 2018

Hydrolyzed Formula Compared With Standard Formula for Preterm Infants

Author Affiliations
  • 1Centre for Reviews and Dissemination, University of York, York, England
  • 2Neonatal Service, Newcastle Hospitals NHS Foundation Trust and University of Newcastle, Newcastle, England
JAMA. 2018;319(16):1717-1718. doi:10.1001/jama.2018.3623

Clinical Question  For preterm infants, is hydrolyzed formula associated with lower rates of feeding intolerance, lower rates of necrotizing enterocolitis, and faster rates of growth compared with standard cow’s milk formula?

Bottom Line  Compared with standard formula, feeding preterm infants hydrolyzed formula is not associated with a lower rate of feeding intolerance, a lower rate of necrotizing enterocolitis, or with faster growth.