A 4-week course of antibiotics was at least as safe and effective as a standard 9-month regimen in preventing active tuberculosis (TB) in people with HIV. Patients also were more likely to complete the shorter course, according to a recent trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).
The study, conducted by the NIAID-funded AIDS Clinical Trials Group, enrolled 3000 teens and adults living with HIV in 10 countries, including the United States. Study participants either resided in an area with a high TB burden or had a skin or blood test revealing latent TB infection.
Rubin R. Just 4 Weeks of Antibiotics Prevents Active TB in People With HIV. JAMA. 2018;319(16):1648. doi:10.1001/jama.2018.4736
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