That diabetes mellitus is not a disease of carbohydrate metabolism alone has been demonstrated by the careful quantitative chemical investigations of the past decade and especially by the study of the disease since the introduction of insulin. Beginning perhaps as a disturbance of carbohydrate metabolism alone, resulting from hypofunctioning of the pancreatic hormone, it remains a relatively innocuous disease as long as carbohydrate metabolism alone is at fault. In this state the patient may live out his normal span of life with a minimal amount of worry about his diet. The harmlessness of diabetes in this stage is attested by the frequency with which it exists and remains unsuspected and undetected until its presence is discovered by a chance urine examination. It is, indeed, difficult to say how deleterious the mere presence of an increased amount of dextrose in the blood and tissues may be. Even this useful and necessary
SOME EFFECTS OF FAULTY FAT METABOLISM IN DIABETES. JAMA. 1929;93(1):34–35. doi:10.1001/jama.1929.02710010040011
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