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Biotech Innovations
May 8, 2018

A Microfluidic Assay to Diagnose Sepsis

JAMA. 2018;319(18):1853. doi:10.1001/jama.2018.5412

A new laboratory test in development may help identify patients with sepsis, a life-threatening condition that remains difficult to diagnose. The work, published in Nature Biomedical Engineering, builds on previous research implicating neutrophil dysfunction as a key player in sepsis.

Having identified unique movement signatures of neutrophils from patients with sepsis in 2014, Daniel Irimia, MD, PhD, an associate professor at Massachusetts General Hospital, and colleagues have now developed a highly accurate diagnostic sepsis score based on the white blood cells’ movements within mazes of channels on a microfluidic chip.