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Article
May 6, 1944

THE CLINICAL USE OF EXTRACTS FROM THE TESTESAND OF SYNTHETIC PRODUCTS HAVING SIMILAR ACTIONS

JAMA. 1944;125(1):15-19. doi:10.1001/jama.1944.02850190017004
Abstract

PHYSIOLOGY  The testis has two functions: (1) the production of spermatozoa by the seminiferous tubules and (2) the production of male sex hormone by the interstitial cells of Leydig. There may be some dissociation of these two functions. Thus an adult male with bilateral cryptorchism may show fairly normal sexual development but be sterile. In most instances, however, testes which do not produce spermatozoa produce deficient quantities of male sex hormone, and several observers1 have presented evidence which suggests that the seminiferous tubules may contribute to the production of hormone. The sex hormones are responsible for the development of the secondary sex characteristics, which in the male include:2

  1. Growth of the external genitalia.

  2. Growth and function of the prostate.

  3. Masculine distribution of hair.

  4. Lowering of the pitch of the voice.

  5. Normal configuration of the skeleton, with normal proportions between the trunk and extremities

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