In the past 2 years, sepsis has received considerable attention from the global community. In 2017, the World Health Assembly passed a resolution urging all 194 UN Member States to implement actions to reduce the burden of sepsis, and for the World Health Organization to report on the public health implications of sepsis and its global consequences.1 It has become clear that early resuscitation targeted to hemodynamic goals is more expensive and no more effective than routine care in high-income countries.2 In Zambia, a protocolized resuscitation strategy actually increased mortality.3 These data and other studies4 continue to suggest that some evidence on sepsis therapy does not generalize on a global scale.
Adhikari NKJ, Rubenfeld GD. qSOFA Score for Patients With Sepsis in Low- and Middle-Income Countries. JAMA. 2018;319(21):2175–2177. doi:10.1001/jama.2018.6413
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