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May 13, 1944


JAMA. 1944;125(2):93-97. doi:10.1001/jama.1944.02850200001001

This consideration of the process of parental influence in relation to incidence of cancer may be divided into three parts. The first of these will cover briefly the different mechanisms by which parents may influence the development of their progeny. The second will discuss the nature of cancer and the various levels or periods in the life of the individual at which the incidence of cancer may be affected or influenced. The third will briefly discuss the experimental evidence derived from animal studies in these specific fields of cancer research.

I. MECHANISMS OF PARENTAL INFLUENCE  By far the best understood and most completely analyzed mechanism of parental influence is that of the chromosomes.1 Long recognized as being constant in number and of individual character as regards shape and size for any given species of animal or plant, their definite and detailed importance is now understood.They are fixed organized

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