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June 5, 2018

Enzyme-Responsive Hydrogels May Help Treat Arthritis

JAMA. 2018;319(21):2161-2162. doi:10.1001/jama.2017.12861

Drug delivery systems that are responsive to levels of disease activity may improve current treatments for conditions whose symptom severity fluctuates over time. With this in mind, investigators have developed a novel drug-releasing gel that effectively responded to inflammatory arthritis flares in a mouse model.

Although systemic therapy is often appropriate for the treatment of inflammatory arthritis, when very few joints are affected, local therapy with intra-articular injections can increase local drug bioavailability and reduce the risk of drug-induced systemic toxicity.