Drug delivery systems that are responsive to levels of disease activity may improve current treatments for conditions whose symptom severity fluctuates over time. With this in mind, investigators have developed a novel drug-releasing gel that effectively responded to inflammatory arthritis flares in a mouse model.
Although systemic therapy is often appropriate for the treatment of inflammatory arthritis, when very few joints are affected, local therapy with intra-articular injections can increase local drug bioavailability and reduce the risk of drug-induced systemic toxicity.
Hampton T. Enzyme-Responsive Hydrogels May Help Treat Arthritis. JAMA. 2018;319(21):2161–2162. doi:10.1001/jama.2017.12861
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