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May 20, 1944

Current Comment

JAMA. 1944;125(3):213-214. doi:10.1001/jama.1944.02850210035014

CHEMOTHERAPY OF FILARIASIS  Filariasis in naturally infected cotton rats has been treated by Culbertson and Rose1 of the Department of Bacteriology, Columbia University, with apparent success, using stibamine glucoside. Florida cotton rats are frequently infected with Litmosoides carinii, the adult parasites usually being found in the pleural spaces with microfilariae constantly given off into the peripheral blood. Several drugs were tested for their therapeutic effects on this natural infection. Among them stibamine glucoside ("neostam") gave particularly favorable results. This is a relatively nontoxic antimony compound, already used with success in the treatment of kala-azar.2 Four doses of from 40 to 60 mg. of this glucoside were administered intramuscularly every week to naturally infected rats, microfilaria tail counts being made daily during the course of the treatment. In a typical case the count was 136 per hundred microscope fields before treating, falling to 52 by the fourteenth day, to

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