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Biotech Innovations
June 12, 2018

Normothermic Preservation Poised to Change Organ Transplants

JAMA. 2018;319(22):2263. doi:10.1001/jama.2018.7234

A recently developed technique that keeps donor organs warm and pumping with blood, oxygen, and other nutrients could shake up a field that’s been relying on low-tech cold storage for decades.

In March, the US Food and Drug Administration granted its first approval for a normothermic system for pretransplant organ preservation to the Organ Care System (OCS) Lung platform from Massachusetts-based TransMedics. Donor lungs in the device are maintained at body temperature, perfused with a solution supplemented with red blood cells, and ventilated with a mixture of oxygen, nitrogen, and carbon dioxide, keeping them in a near-physiological state.