Over the past 3 decades, mortality rates for acute myocardial infarction (MI) have declined significantly in large part due to improved evidence-based revascularization techniques, medical therapies, and systems of care. Yet, patients with acute MI represent a diverse group with varying causes for their infarction. Recognizing this, in 2007, the Task Force for the Redefinition of MI created the Universal Definition of MI consensus document, which introduced 5 subtypes of MI (Table).1 One common subtype, type 2 MI, is defined as an MI driven by a myocardial oxygen supply and demand mismatch in the absence of coronary thrombosis.