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Global Health
June 19, 2018

Preemptive Antibiotic Use Reduces Childhood Deaths

JAMA. 2018;319(23):2371. doi:10.1001/jama.2018.7854

Twice-yearly mass distributions of the oral broad-spectrum antibiotic azithromycin to preschool children in 3 sub-Saharan African countries reduced child mortality, according to research from the MORDOR Study Group, an international collaboration of investigators.

The researchers enrolled 190 238 healthy children aged 1 to 59 months from 1533 communities in Malawi, Niger, and Tanzania in a cluster-randomized trial. Randomization and intervention were conducted at the community level. The children received either 1 dose of azithromycin or placebo every 6 months for 2 years.