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July 27, 1929


Author Affiliations


From the Robert B. Brigham Hospital.

JAMA. 1929;93(4):259-263. doi:10.1001/jama.1929.02710040011004

A paper 1 on metabolism studies in chronic arthritis was published in September, 1927. Two hundred cases were reported at that time and may be thus summarized:

In 200 cases of chronic arthritis there was an abnormal metabolic rate in 39 per cent; 20 per cent were minus and 19 per cent plus. The metabolic rate was unaffected by age, sex, duration or activity of the disease. The infectious arthritic patients were 21 per cent plus to 17 per cent minus. The atrophic patients were 15 per cent plus to 18 per cent minus. The hypertrophic patients were 19 per cent plus to 27 per cent minus. An interesting drop in metabolic rate was noted in some cases after the administration of thyroid extract, with an improvement in the stability and regularity of the graphic metabolic chart.

Feeling that more cases were necessary to this study, I have continued the