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Article
July 27, 1929

OVARIAN RESPONSES: DIFFERENCES ELICITED BY TREATMENT WITH URINE FROM PREGNANT WOMEN AND BY FRESHLY IMPLANTED ANTERIOR LOBE

Author Affiliations

NEW YORK

From the Department of Anatomy, Columbia University College of Physicians and Surgeons.

JAMA. 1929;93(4):276-277. doi:10.1001/jama.1929.02710040028009
Abstract

Attention has been directed recently toward human urine as a source of supply of several hormonal substances. Aschheim and Zondek 1 reported constant and characteristic responses in the ovary of the immature mouse to injection of the whole urine of pregnancy which they have ascribed to a hormone of the anterior lobe. Louria and Rosenzweig2 have reported similar results.

It is not to be denied that the urine from pregnant women elicits an ovarian response similar in some respects to that induced by implants of the fresh anterior lobe. Other features of this response, however, differ greatly from those produced by the fresh gland. It is to these atypical features which appear not to have been appreciated by recent workers in this field, and which make untenable their assumption that this is a typical anterior pituitary response, that attention is called here.

In the present experiments, immature mice, from

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