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Comment & Response
July 3, 2018

Conflict of Interest in Nutrition Research—Reply

Author Affiliations
  • 1Stanford Prevention Research Center, Stanford University, Stanford, California
JAMA. 2018;320(1):94-95. doi:10.1001/jama.2018.5678

In Reply The letters by Dr Ludwig and colleagues and Drs Bero and Grundy offer an opportunity to discuss potential trade-offs and clarify potential misunderstandings regarding our proposal.

Greater transparency and a broader definition of disclosure-worthy information in nutrition are both essential, given the unique barriers to knowledge that threaten specifically nutrition science.1 Most effect sizes for nutritional risk factors and nutrition-related interventions are tiny. Confounding is influential, and diet is measured with notoriously faulty memory-based assessments. Much of nutrition science may be a null field with few true discoveries among endless analyses and claims.2 Average effect sizes may sometimes just reflect average bias.