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Comment & Response
July 10, 2018

Low-Fat vs Low-Carbohydrate Diets and Weight Loss

Author Affiliations
  • 1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
  • 2Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
JAMA. 2018;320(2):202-203. doi:10.1001/jama.2018.6244

To the Editor In a 12-month, behavior modification diet intervention study, Dr Gardner and colleagues1 compared the effects of a healthy low-fat diet with a healthy low-carbohydrate diet on weight loss among 609 overweight adults. The authors did not find a significant difference in weight loss between the 2 diet intervention groups, in line with results from several previous studies.2 Different from traditional diet intervention trials, 1 of the primary aims of the DIETFITS study was to test diet × genotype pattern interactions on weight loss in response to the diet intervention. The authors did not observe significant diet × genotype pattern interactions and concluded that there was no significant difference in genotype pattern associated with the dietary effects on weight loss.

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