Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics

Clinical Question  In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events?

Bottom Line  Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low–quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.