In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events?
Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low–quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.
Goldenberg JZ, Mertz D, Johnston BC. Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics. JAMA. 2018;320(5):499–500. doi:10.1001/jama.2018.9064
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