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July 22, 1944

A SUGGESTED THERAPY FOR THE PREVENTION OF GRANULOCYTOPENIA INDUCED BY THIOUREA

JAMA. 1944;125(12):847. doi:10.1001/jama.1944.72850300003007a
Abstract

The administration of thiourea and its derivatives and the sulfonamides to animals results in the development of a state of hypothyroidism.1 These substances produce this effect by interfering with the synthesis of normal thyroid hormone.2 Clinical studies have shown that thiourea and thiouracil are effective in the treatment of hyperthyroidism.3 The possibility of the occurrence of agranulocytosis in patients treated with these drugs has been indicated in the work of Astwood.4 The present work will demonstrate that a neutrophilic granulocytopenia also results from feeding thiourea to adult rats. Since the granulocytopenia produced in weanling rats fed sulfonamides has been corrected by liver,5 it was decided also to test the effects of solubilized liver6 on the thiourea-induced neutropenia.

Eighteen adult male rats weighing 200 to 240 Gm. were fed a standard laboratory ration containing 0.5 per cent thiourea for fifty-eight days. Six animals of another

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