To the Editor The Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) trial1,2 compared opioids with nonopioid analgesics over 12 months in primary care patients with chronic low back pain or osteoarthritis pain of the hip or knee and concluded that the results do not support initiation of opioid therapy for such patients. Further scientific discussion of the study is necessary.
Bigal ME. Opioids vs Nonopioids for Chronic Back, Hip, or Knee Pain. JAMA. 2018;320(5):507. doi:10.1001/jama.2018.6949
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